Infection

By admin On Dec 13, 2022

Ovid: Pediatrics

Editors: Tornetta, Paul; Einhorn, Thomas A.; Cramer, Kathryn E.; Scherl, Susan A.

Title: Pediatrics, 1st Edition

> Table of Contents > Section II: – Emergency Department > 17 – Infection

Infection

Jon R. Shereck

Richard M. Schwend

Musculoskeletal infections in children are common
conditions likely to be encountered by all orthopaedic surgeons. The
diagnosis of bone or joint sepsis is often difficult to make. The child
can present with many different signs and symptoms (Box 17-1), and there are multiple conditions that can mimic infection (Box 17-2).
Although evaluation and treatment of orthopaedic infections is
sometimes controversial, by following basic principles, significant
sequela can be prevented.

ACUTE HEMATOGENOUS OSTEOMYELITIS

PATHOGENESIS

Etiology

Staphylococcus aureus (most common)
Group A Streptococcus
Streptococcus pneumoniae
Group B β-hemolytic Streptococcus (usually in neonates)

Epidemiology

Half of affected children are younger than 5 years of age, one-third are younger than 2 years of age.
Male-to-female ratio is up to 4 to 1.
Common in warmer climates; peak incidence in late summer or early fall
Most common in metaphyseal region of
lower extremity long bones. Seen in locations with the fastest growth
rate, such as distal femur

Pathophysiology

Trauma to the metaphysis and bacteremia have a combined role in initiating osteomyelitis.
Blood-borne bacteria are deposited in metaphyseal venous sinusoids.
Medullary vessels thrombose.
This inhibits access of inflammatory cells for proper immune response.
Purulent material is produced. Infection
spreads through Volkmann canals or the haversian bone system.
Subperiosteal abscess may form.
Due to the compromised vascularity of
cortical bone, a sequestrum (loosely adherent piece of dead bone) may
develop. An involucrum (new bone) may form over the sequestrum. Poor
vascularity may lead to chronic osteomyelitis.
Joints where the metaphysis lies within the capsule are at particular risk for septic arthritis:
- □ Proximal femur and hip
- □ Proximal humerus and glenohumeral joint
- □ Lateral distal tibia and ankle
- □ Radial neck in the elbow

BOX 17-2 DIFFERENTIAL DIAGNOSIS OF ORTHOPAEDIC INFECTIONS

Osteomyelitis

Transient synovitis
Soft tissue abscess
Cellulitis
Pyogenic arthritis
Fracture
Thrombophlebitis
Rheumatic fever
Bone infarction
Gaucher disease
Malignancy
- Osteosarcoma
- Ewing sarcoma
- Leukemia
- Neuroblastoma
- Wilms tumor

Septic Arthritis

Transient synovitis
Rheumatic fever
Leukemia
Cellulitis
Juvenile arthritis
Osteomyelitis
Hemophilia
Lyme arthritis
Henoch-Schönlein purpura
Hemiarthrosis
Viral or reactive arthritis
Chondrolysis
Sickle cell crisis
Lillonodular synovitis
Legg-Calvé-Perthes disease
Slipped capital femoral ephiphysis

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DIAGNOSIS

Criteria for diagnosing osteomyelitis are outlined in Boxes 17-3 and 17-4.

History

History of recent or concurrent infection in about 50% of patients
Preceding trauma in up to 50%
Duration of symptoms typically less than 2 weeks
Continuous bone pain for at least 24 hours

Physical Examination

Local signs of erythema, swelling, and
warmth are seen with advanced infection. If cellulitis is present, this
may indicate an underlying abscess.
Pain is not well localized if the infection involves the spine or pelvis
Signs are different for different ages.
- □ Neonates: swelling at the affected site
  due to an easily penetrated thin periosteum. However, the only finding
  may be a systemically ill neonate, or one who is irritable and failing
  to thrive.
- □ Toddler and young children: pain,
  usually point tenderness, is seen in 50%. A limp or inability to bear
  weight is commonly seen with infections of the lower extremity.
- □ Adolescents: may be more locally tender because of more resilient and tense tissues.

BOX 17-3 MORREY AND PETERSON CRITERIA FOR THE DIAGNOSIS OF OSTEOMYELITIS

Definite: The pathogen is isolated from the bone or adjacent soft tissue, or there is histologic evidence of osteomyelitis.

Probable: A blood culture is positive in the setting of clinical and radiographic features of osteomyelitis.

Likely: Typical clinical
findings and definite radiographic evidence of osteomyelitis are
present, and there is a response to antibiotic therapy.

Adapted from Morrey BF, Peterson HA. Hematogenous pyogenic osteomyelitis in children. Orthop Clin North Am 1975;6:935-951.

BOX 17-4 PELTOLA AND VAHVANEN CRITERIA FOR THE DIAGNOSIS OF OSTEOMYELITIS

The diagnosis is established when two of the following four criteria are met:

Pus is aspirated from bone.
A bone or blood culture is positive.
The classic symptoms of localized pain, swelling, warmth, and limited range of motion of the adjacent joint are present.
Radiographic features characteristic of osteomyelitis are present.

Adapted from Peltola H, Vahvanen V. A comparative study
of osteomyelitis and purulent arthritis with special reference to
aetiology and recovery. Infection 1984;12:75-79.

Laboratory Features

White blood cell (WBC) count may be normal in up to 70% of patients.
Erythrocyte sedimentation rate (ESR):
- □ Elevated in more than 90% of patients, but is nonspecific.
- □ Levels rise slowly and peak in 3 to 5
  days, so may be normal if child presents early in the course of the
  infection. The neonate, patient with sickle cell disease, or the child
  who is taking steroids may not have an elevated ESR.
C-reactive protein (CRP):
- □ Acute phase protein synthesized by the liver.
- □ Elevated in as many as 97% of patients.
- □ Levels rise rapidly and peak in 2 days. CRP is quick to decline (within 6 hours) after initiation of appropriate therapy.
Blood cultures are positive in 30% to 60% of patients.
Cultures taken from involved bone:
- □ Have a higher yield of pathogens (positive in up to 75% of patients) and may be the only positive culture site in 28%.
- □ Gram stain should be performed at same time.
- □ Consider fine-needle biopsy to obtain material for histologic examination.
Surgical biopsy should be sent for histopathology when débridement is clinically indicated.

Radiologic Features

Plain radiographs
- □ Do not accept incomplete or poor quality films. Need two orthogonal views of the involved area.
- □ Soft-tissue swelling is evident within
  48 hours of onset of infection; soft tissue planes may be poorly
  visualized. Always look for subtle evidence of free air
  
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  in the tissues to suggest an anaerobic, gas-producing infection.
- □ Comparison views of the contralateral extremity may be helpful.
- □ Periosteal new bone formation may be evident by 5 to 7 days.
- □ Osteolytic changes require bone mineral loss of 30% to 50%. May not be apparent until 10 to 14 days after onset.
Technetium-99m bone scintigraphy
- □ Useful if of normal radiographs but still clinical suspicion of osteomyelitis.
- □ Sensitivity: 84% to 100%. Specificity: 70% to 96%. Sensitivity is decreased in the neonate.
- □ Prior aspiration does not give false-positive results.
- □ “Cold” scans in late stages of infection.
  - □ Very worrisome for a severe infection or osteonecrosis.
  - □ Decreased uptake due to relative
    ischemia caused by increased pressure from purulent material: leads to
    vascular congestion and osteonecrosis
  - □ Positive predictive value of up to 100%
Magnetic resonance imagine (MRI)
- □ Sensitivity: 88% to 100%. Specificity: 75% to 100%
- □ Very useful for suspected spinal and
  pelvic infections. Consider using if patient has not responded after 2
  days of antibiotic therapy
- □ Excellent imaging modality for planning surgical approaches
- □ T1-weighted and short-tau inversion recovery (STIR) images are most useful for detection of acute osteomyelitis
Computed tomography (CT)
- □ Most useful in detection of gas in soft tissue infections and in identification of sequestra in chronic osteomyelitis
Ultrasound
- □ Detects fluid collections and soft tissue swelling
- □ Advantages: low cost, relative availability, noninvasive, nonionizing radiation, no sedation required
- □ Disadvantages: lack of specificity, operator dependent, inability to image marrow or show cortical detail

Diagnostic Workup

A complete and thorough history and physical examination is performed. Be anatomically specific about the location of the pain.
Laboratory and imaging studies as previously described
Once an anatomic source is localized,
aspiration is used to obtain the organism. Surgical biopsy can also be
used to obtain the organism. The decision to use surgery requires
clinical judgment. It usually is performed to drain pus, débride
necrotic tissue, or when the patient has not responded to appropriate
antibiotic therapy.

TREATMENT

Morrissey has advocated the following treatment principles for infection:

Find the organism, which can generally be identified in 50% to 70% of cases.
Use appropriate antibiotics.
Deliver the antibiotic to the area of infection.
Stop the tissue destruction: typically by surgical drainage and débridement.
Once the diagnosis has been made and
blood and tissue cultures obtained, begin empiric intravenous (i.v.)
antibiotics. Since most infections are caused by S. aureus, group A Streptococcus, or Pneumococcus, Cefazolin (Kefzol) 50 mg per kg per dose, every 8 hours, maximum dose 12 g per day is a safe and reasonable initial choice.
Nafcillin or oxacillin are reasonable initial alternatives.
Consider the following special situations:
- □ Neonates: add gentamicin or cefotaxime to the regimen.
- □ Allergy to penicillin: cefazolin is the antibiotic of choice.
- □ Allergy to both penicillin and cephalosporins: clindamycin or vancomycin.
- □ Methicillin-resistant S. aureus is suspected: vancomycin.
- □ Consider infectious disease consultation for these special situations.
Aspiration or biopsy is indicated if no improvement after 36 to 48 hours of appropriate i.v. antibiotics.
Switching to oral antibiotics: very
subjective and clinical judgment is required. The patient should appear
well, have a normal temperature and pulse, have a markedly improved
clinical examination, and be able to take oral medication.
Intravenous antibiotics may be continued longer if:
- □ Initiation of therapy is markedly delayed and necrotic tissue is suspected.
- □ Poor response, or no response, after empiric i.v. therapy.
- □ Patient is unable to take oral medications.
- □ There is no effective oral antibiotic for the identified organism or if there is a very unusual organism.
Duration of therapy is determined by
clinical improvement. Traditionally, antibiotics are used for 4 to 6
weeks. Follow clinical response and ESR.
Indications for surgical débridement
- □ Evidence of an intraarticular, subperiosteal, intramedullary, or soft-tissue abscess
- □ Sequestrum
- □ Contiguous focus of infection
- □ Poor response to appropriate i.v. antibiotics
Surgical management
- □ Drain the soft tissue abscess
- □ Incise the periosteum
- □ Drill the cortex
- □ Remove all dead bone
Postoperative immobilization in a splint or cast, especially if at risk for a pathologic fracture.

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SEPTIC ARTHRITIS

PATHOGENESIS

Etiology

Neonates: group B Streptococcus, S. aureus, Gram-negative bacilli
1 month to adolescent: S. aureus, S. pneumoniae, S. pyogenes
Adolescents: may also see Neisseria gonorrheae
Haemophilus influenzae B rare unless child has not been immunized

Epidemiology

Septic Arthritis

Most common in children less than age 2 years of age
More common in boys than girls

Pathophysiology

Hematogenous seeding of bacteria in the
rich vascular network in the subsynovial layer is present, which then
progresses into the joint.
Other possible routes for septic arthritis to develop:
- □ Local spread from a contiguous infection, such as an intraarticular osteomyelitis.
- □ Penetrating trauma or surgical infection.
- □ Percutaneous fixation pins that are intraarticular, such as in the knee.
Acute inflammatory stage:
- □ Polymorphonuclear cells (PMNs) rapidly enter the joint space.
- □ Plasma proteins cross the synovial membrane, resulting in a tense effusion.
- □ Leading to significant pain even at rest
Articular cartilage can be destroyed in response to infection by two mechanisms:
- □ Degradation by proteolytic enzymes (e.g., collagenase, proteinases).
- □ Interleukin-1 from monocytes mediates the release of acid and neutral proteases by chondrocytes and synoviocytes.
Early diagnosis and treatment is
essential to limiting articular cartilage destruction. If treatment is
delayed beyond 4 days, articular damage can be permanent.

DIAGNOSIS (BOX 17-5)

History

May have a history of a recent upper
respiratory infection or local soft tissue infection, preceding trauma,
fever, malaise, and pain
Pain at rest, limp, and limited spontaneous motion
Fever, which may not be present if small joint involved
Consider the possibility of an altered immune status.

Physical Examination

Patients may appear more ill compared with osteomyelitis.
Young children may be very irritable (see Box 17-1).
Pain is present at rest and is increased with passive joint motion and axial loading.
If the hip joint is involved, it is
typically held in external rotation, abduction, and mild flexion to
maximize the joint volume and decrease the resting pressure.
The neonate may have mild or absent signs and symptoms.
When a septic hip is suspected, consider
adjacent sites as the primary cause of infection, including pelvic
abscess, infection of any of the muscles about the hip and pelvis,
pelvic osteomyelitis, or proximal femur osteomyelitis. The psoas sign
of pain on extension and internal rotation of the hip is present in as
many as 89% of patients with primary pyogenic psoas abscess.

Laboratory Features

WBC count elevated in 30% to 60% of patients
- □ PMNs elevated in 60% to 80%
ESR elevated in more than 90% of
patients, but not elevated early in the course of the infection. It is
highly sensitive, but nonspecific.
CRP
- □ Helps detect associated septic arthritis in patients with acute hematogenous osteomyelitis
- □ If CRP concentration by the third day
  is 1.5 times the level on admission, there is a high likelihood that
  associated septic arthritis is present.
Blood cultures are positive in 40% to 50%
of patients and are the only positive culture site in 12%. Up to 70%
yield if both blood and joint cultures obtained.
A large-bore (20-gauge or larger) needle
aspiration should be obtained on all septic joints. There is little
risk of seeding a bone or joint in an area of cellulites.
- □ Hip joint aspiration: consider using
  arthrographic or ultrasound guidance. Patient should be sedated or
  under general anesthesia.
Synovial fluid analysis:
- □ WBC greater than 50,000/mL with 90% PMNs is indicative of bacterial infection.
- □ Glucose level: synovial fluid/serum glucose ratio of less than 0.5, or synovial fluid glucose 40 mg/dL less than serum level.
- □ Positive mucin clot test: assesses
  integrity of hyaluronic acid of joint fluid. Place a drop of glacial
  acetic acid into the fluid while stirring with a glass rod. In the
  presence of bacteria, the consistency of the fluid resembles that of
  curdled milk due to degraded hyaluronic acid.
- □ Gram stain is positive in about 50% of cases.
A Mantoux skin test, or purified protein derivative (PPD) skin test should be placed if tuberculosis is a possibility.

Radiologic Features

Plain radiographs
- □ Frequently normal
- □ Changes are subtle and may include:
  
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  - □ Soft tissue edema, loss of tissue planes
  - □ Joint space widening is seen with capsular distention, especially in the infant hip joint
  - □ Subluxation or dislocation of the involved joint, particularly in the neonate
  - □ Epiphyseal ischemic necrosis
  - □ Associated metaphyseal or epiphyseal osteomyelitis
Bone scan
- □ Rarely useful to diagnose septic
  arthritis, but can be helpful when the exact location of the septic
  joint is difficult to identify.
- □ A “cold bone scan” of the hip is particularly worrisome.
- □ In a septic joint, the distribution of uptake is uniform within the joint capsule; asymmetric uptake indicates osteomyelitis.
MRI
- □ Used in patients with septic hip
  arthritis who have not responded to conventional therapy: useful in
  delineating areas of residual infection and defining associated
  osteomyelitis.
- □ Very helpful for imaging the pelvis if an abscess is suspected.
CT: no useful role in septic arthritis
Ultrasound
- □ More sensitive (almost 100%) than plain
  radiography in diagnosing an effusion. However, it is not specific in
  determining whether the effusion is infectious.
- □ Very useful in evaluating suspected
  sepsis of the hips. Both hips should be imaged along the axis of the
  femoral neck. Affected hip will show asymmetry of the capsule-to-bone
  distance of 2 mm or more, indicating an intraarticular effusion.
  Echogenicity suggests a septic arthritis or clotted hemorrhagic
  collections, but is not very specific.
- □ Results must be combined with clinical impression to determine need for hip aspiration.
- □ Aspiration can be performed under guidance.

Diagnostic Workup

A septic hip arthritis clinical practice guideline (CPG) algorithm has been proposed by Kocher and colleagues (Algorithm 17-1). It includes a thorough diagnostic workup protocol as well as the appropriate treatment.
- □ Compared with previous standard practice, use of this CPG has resulted in:
  - □ Less frequent use of bone scan (13% vs. 40%)
  - □ Earlier conversion to oral antibiotics (3.9 vs. 6.9 days)
  - □ Lower use of inappropriate surgical drainage (53% vs. 87%)
  - □ Lower rate of nonrecommended antibiotic course (7% vs. 93%).
  - □ Shorter hospital stay (4.8 vs. 8.3 days)
- □ Despite less extensive diagnosis and treatment, there was no less successful clinical outcome with use of the CPG.
If clinical suspicion is high after a
thorough history and physical and is supported by initial lab values or
radiographs, then aspiration of the involved joint is used to confirm
the presence of infection.
- □ CRP, ESR, complete blood count (CBC)
  with differential, Lyme titer, blood culture, throat culture/rapid
  strep, anti-strepolysin (ASLO).
- □ Plain radiographs
- □ If there is uncertainty about the
  presence of a septic effusion about the hip after the initial
  evaluation, ultrasonography is of diagnostic value to confirm the
  presence of an effusion. Confirmed hip effusion with a clinical picture
  suggestive of septic arthritis should receive diagnostic aspiration.
Septic arthritis can still be present despite negative cultures (Box 17-5).

BOX 17-5 MORREY AND PETERSON CRITERIA FOR THE DIAGNOSIS OF SEPTIC ARTHRITIS IN PATIENTS WITH NEGATIVE CULTURES

The diagnosis is established when five of the following six criteria are present:

Temperature exceeds 38.3°C
Swelling of the suspected joint is present. This is not always obvious for a deep joint such as the hip
Pain that is exacerbated with movement
Systemic symptoms
No other pathologic processes are present
- Satisfactory response to antibiotic therapy

Adapted from Morrey BF, Peterson HA. Hematogenous pyogenic osteomyelitis in children. Orthop Clin North Am 1975;6:935-951.

TREATMENT

Blood and joint cultures should be obtained prior to administration of antibiotics.
Open arthrotomy for patients with hip involvement.
Septic knee arthritis does well with arthroscopic lavage.
Empiric antibiotic therapy should be
initiated. Cefazolin (Kefzol) 50 mg/kg per dose, every 8 hours, maximum
dose 12 g/day. Nafcillin or oxacillin are reasonable initial
alternatives.
Special situations are similar to those described for osteomyelitis. Ceftriaxone for possible H. influenzae B or N. gonorrhea infection.
Final antibiotic choice is directed by the culture and sensitivity results.
Duration of i.v. antibiotics is based on
the clinical response. The CPG typically averaged 4 days of i.v.
antibiotic before switching to an oral antibiotic. Serum bactericidal
levels are not routinely obtained.
Total duration of antibiotics for septic arthritis is typically about 3 weeks. Follow clinical response and ESR.

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Algorithm 17-1 (continued)

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SPECIAL SITUATIONS

SUBACUTE HEMATOGENOUS OSTEOMYELITIS

Slow, insidious onset. Commonly presents as a metaphyseal lesion such as a Brodie abscess or an epiphyseal lesion
Can mimic other lesions such as chondroblastoma, eosinophilic granuloma, osteoid osteoma, or osteoblastoma
Treat with i.v. antibiotics. Surgery if unresponsive.

CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS

Inflammatory process of the bone with no clear etiology
Multiple lesions, normal WBC count. Nonspecific radiographs with poorly defined metaphyseal lesions
Symptoms resolve, then recur, and can continue to recur for several years.
Treat with nonsteroidal inflammatory drugs.

OSTEOMYELITIS AND SEPTIC HIP ARTHRITIS IN THE NEONATE

Group B Streptococcus most common; however, many different organisms can be involved.
Immature immune system. Infection can be
extensive with multiple sites. Symptoms are often mild or minimal. In
the septic newborn one should always suspect a bone or joint infection.
Infections may be related to an indwelling i.v. catheter or may occur in the apparently healthy newborn after discharge.
The hip is very susceptible to infection,
ischemic necrosis, septic dislocation, and physeal injury. Aspiration
of a suspected hip infection should always be performed and surgery
provided whenever pus is found.
Intravenous rather than oral antibiotics

TRANSIENT SYNOVITIS OF THE HIP

Must always be differentiated from septic arthritis of the hip
Considered to be an immune-mediated mechanism after a viral infection
Less signs of systemic illness or joint inflammation. More comfortable at rest
Kocher and colleagues looked at the following four predictors of septic arthritis versus transient synovitis:
- □ History of fever
- □ Non-weightbearing
- □ ESR ≥40 mm/hour
- □ WBC >12,000 cells/mm³
Probability of septic arthritis with positive predictors:
- □ 1 of 4:2—5%
- □ 2 of 4:33—62%
- □ 3 of 4:93—97%
- □ 4 of 4:99—99.8%

POSTGASTROENTERITIS ARTHRITIS

Joint involvement after infection with intestinal pathogens: Salmonella, Shigella, Yersinia, Campylobacter
Positive stool culture

REITER SYNDROME

Oral and genital lesions. May have eye symptoms
In the sexually active child, positive Gonococcus or Chlamydia cultures confirm the diagnosis.

SACROILIAC JOINT INFECTIONS

Pain in gluteal region, abdomen, or lumbar region
FABER (flexion, abduction, external rotation) test positive on physical examination
Initially, radiographs are normal. MRI is
very useful in the pelvic region and can detect an adjacent soft tissue
abscess, particularly when the patient is not responding to antibiotic
treatment.
Blood and stool cultures are obtained and are positive in 60%. Usually S. aureus, but can be caused by Salmonella.
Treatment: i.v. antibiotics to cover S. aureus

CULTURE-NEGATIVE AND GONOCOCCAL SEPTIC ARTHRITIS

Rash, tenosynovitis especially on the dorsum of the hands and polyarticular arthritis are suspicious findings for N. gonorrheae.
Culture all mucous membranes.
Report to protective services if N. gonorrheae infection is confirmed in a young child.
In future, polymerase chain reaction (PCR) may be useful for diagnosis.
Ceftriaxone (50 mg/kg/day) is used for possible H. influenzae B or N. gonorrhea infection.

LYME ARTHRITIS

History of documented tick bite in known endemic area
Typical rash of erythema migrans
Obtain Lyme titer if diagnosis considered.

VIRAL ARTHRITIS

Multiple small joints
May mimic septic arthritis, especially if caused by parvovirus

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TUBERCULOSIS

Bone or joint involvement is seen in 10% of tuberculosis cases.
Systemic symptoms, and mild pain are often seen.
The spine is the most common musculoskeletal site and is involved in 50%, with kyphosis the most common deformity.
PPD
Prolonged and monitored antimicrobial therapy is mainstay of treatment.

DISCITIS

The pediatric disc receives its blood
supply directly from the adjacent bone, which makes the disc
susceptible to hematogenous infection.
Findings include fever, systemic illness,
refusal to walk, or abdominal pain in the younger child. Back pain,
night pain, and stiffness in flexion are more common in the older child.
Blood cultures are positive in 50%, CRP is markedly elevated, and ESR is moderately elevated.
Plain radiographs show disc space
narrowing and occasionally end-plate changes. Bone scan is more
sensitive and can diagnose the infection about a week earlier than can
plain radiographs.
Initially treat with antistaphylococcal antibiotics. Casting or bracing is used for comfort.

SICKLE CELL DISEASE

Patients are at risk for osteomyelitis due to microvascular disease and bony infarcts.
Vasoocclusive pain crisis (infarction) more common than osteomyelitis. Symptoms resolve sooner.
Osteomyelitis produces high fever and an
ill patient. There is an elevated ESR and positive blood cultures.
Aspiration is the best diagnostic test to confirm infection. Surgical
drainage is usually necessary.
S. aureus is still the most common organism in osteomyelitis in sicklers, but salmonella is more common in sicklers than in the general population.

PUNCTURE WOUNDS

Classically, a nail through a dirty, old athletic shoe
Small percentage develops osteomyelitis or septic arthritis by direct inoculation into the bone or joint. Typically caused by Pseudomonas.
Confirmed deep infection with Pseudomonas requires surgical débridement and i.v. antibiotic coverage.

PEARLS

Septic arthritis of the hip is a true surgical emergency, especially in the neonate.
Ultrasound of the hip is very sensitive to confirm an effusion, which then needs to be explained.
Beware of the “cold” bone scan: associated with worse prognosis and suggestive of ischemia.
Obtain infectious disease consultation for:
- Unusual organism: S. pneumoniae, H. influenzae, gram-negative
- Unusual host: sickle cell, immunocompromised, malabsorption
- Unusual site: multiple joints, bones, or multiple organs
If patient unresponsive to antibiotic treatment consider:
- Wrong diagnosis
- Wrong antibiotic, dose, or route of administration
- An abscess or undrained pus
- Immune deficiency
Pus should be drained surgically when:
- Purulence on aspiration
- Radiographic evidence of purulence/abscess: hole in bone, fluid collection
- Unresponsive to appropriate antibiotics