Editors: Tornetta, Paul; Einhorn, Thomas A.; Damron, Timothy A.
Title: Oncology and Basic Science, 7th Edition
Copyright ©2008 Lippincott Williams & Wilkins
> Table of Contents > Section IV – Basic Science > 27 – Infectious Disorders of Bone and Joint > Introduction
Introduction
The clinical presentation of infection is a function of
time, location, and the nature of the organism and host. Acute
bacterial disorders represent urgent clinical problems that, left
untreated, may rapidly lead to joint destruction or bone infarction,
sequestration, and development of chronic osteomyelitis. By contrast,
the presentation of infection from some bacteria and all other types of
organisms tends to be indolent. The clinical presentation, radiologic
findings, and morphologic manifestations of osteomyelitis are
influenced by the blood supply to bone and joint and by the structural
architecture of bone, which is composed of living cells contained in a
nonexpandable inorganic framework.
time, location, and the nature of the organism and host. Acute
bacterial disorders represent urgent clinical problems that, left
untreated, may rapidly lead to joint destruction or bone infarction,
sequestration, and development of chronic osteomyelitis. By contrast,
the presentation of infection from some bacteria and all other types of
organisms tends to be indolent. The clinical presentation, radiologic
findings, and morphologic manifestations of osteomyelitis are
influenced by the blood supply to bone and joint and by the structural
architecture of bone, which is composed of living cells contained in a
nonexpandable inorganic framework.
Classification
Infection in bone and joints can be classified by organism type, pathologic response, and presentation as follows:
This review will focus on specific disease mechanisms of
the infectious diseases of bone and joint. In each instance, the type
of organism and location, linked to the circulation and structure of
bone and joint, will determine the presenting manifestations and
prognosis.
the infectious diseases of bone and joint. In each instance, the type
of organism and location, linked to the circulation and structure of
bone and joint, will determine the presenting manifestations and
prognosis.